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Article

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.

The Journal of experimental medicine - 6 Nov 2017

Chen Xiaojing, Poncette Lucia, Blankenstein Thomas

Abstract excerpt

For thymic selection and responses to pathogens, T cells interact through their αβ T cell receptor (TCR) with peptide-major histocompatibility complex (MHC) molecules on antigen-presenting cells. How the diverse TCRs interact with a multitude of MHC molecules is unresolved. It is also unclear how humans generate larger TCR repertoires than mice do. We compared the TCR repertoire of CD4 T cells selected from a...

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Identifiers

PMID: 28835417
DOI: 10.1084/jem.20161784
PMCID: PMC5679170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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