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Comparative analysis of CDR 3 regions in paired human αβ CD 8 T cells

25 Jun 2019

Abstract excerpt

The majority of human CD8 cytotoxic T lymphocytes express αβ T-cell receptors that recognize peptide-MHC class I complexes. Considerable attention has been devoted to TCR β repertoires, but study of TCR α chains has been limited. To gain a better understanding of the features of CDR3α and CDR3β in paired samples, we comprehensively analyzed 776 unique paired αβ TCR CDR3 regions in this study. We found that (I)...

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PMID: 31237075
DOI: 10.1002/2211-5463.12690

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