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Article

Overlap and Effective Size of the Human CD8 <sup>+</sup> T Cell Receptor Repertoire

1 Sept 2010

Abstract excerpt

Diversity in T lymphocyte antigen receptors is generated by somatic rearrangement of T cell receptor (TCR) genes and is concentrated within the third complementarity-determining region 3 (CDR3) of each chain of the TCR heterodimer. We sequenced the CDR3 regions from millions of rearranged TCR beta chain genes in naïve and memory CD8(+) T cells of seven adults. The CDR3 sequence repertoire realized in each...

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PMID: 20811043
DOI: 10.1126/scitranslmed.3001442

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