Article
Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.
Environmental and molecular mutagenesis - 1 Jun 2014
Avlasevich Svetlana L, Phonethepswath Souk, Labash Carson, Carlson Kristine, Torous Dorothea K, Cottom John, Bemis Jeffrey C, MacGregor James T, Dertinger Stephen D
Abstract excerpt
Diethylnitrosamine (DEN) is a genotoxic carcinogen, but in vivo DNA-damaging activities are not usually evident in hematopoietic cells because the short-lived active metabolite is formed mainly in the liver. DEN therefore represented an interesting case for evaluating the performance characteristics of blood-based endpoints of genotoxicity that have been automated using flow cytometric analysis-frequency of...
Topics
- Alkylating Agents
- Animals
- DNA Damage
- Diethylnitrosamine
- Male
- Membrane Proteins
- Micronucleus Tests
- Mutagenicity Tests
- Mutation
- Mutation Rate