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Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.

Environmental and molecular mutagenesis - 1 Jun 2014

Avlasevich Svetlana L, Phonethepswath Souk, Labash Carson, Carlson Kristine, Torous Dorothea K, Cottom John, Bemis Jeffrey C, MacGregor James T, Dertinger Stephen D

Abstract excerpt

Diethylnitrosamine (DEN) is a genotoxic carcinogen, but in vivo DNA-damaging activities are not usually evident in hematopoietic cells because the short-lived active metabolite is formed mainly in the liver. DEN therefore represented an interesting case for evaluating the performance characteristics of blood-based endpoints of genotoxicity that have been automated using flow cytometric analysis-frequency of...

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PMID: 24574022
DOI: 10.1002/em.21862

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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