Article
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
The Journal of clinical investigation - 1 Sept 2017
Sadiku Pranvera, Willson Joseph A, Dickinson Rebecca S, Murphy Fiona, Harris Alison J, Lewis Amy, Sammut David, Mirchandani Ananda S, Ryan Eilise, Watts Emily R, Thompson A A Roger, Marriott Helen M, Dockrell David H, Taylor Cormac T, Schneider Martin, Maxwell Patrick H, Chilvers Edwin R, Mazzone Massimilliano, Moral Veronica, Pugh Chris W, Ratcliffe Peter J, Schofield Christopher J, Ghesquiere Bart, Carmeliet Peter, Whyte Moira Kb, Walmsley Sarah R
Abstract excerpt
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance between appropriate, predominantly neutrophil-mediated pathogen clearance and resolution of the innate immune response. We demonstrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.