Article

Tyrosine halogenation converts α-defensins into potent immunomodulators

2023-11-02

Abstract excerpt

Neutrophils are immune cells that eliminate microbes using a powerful arsenal of reactive oxygen species, hypohalous acids, proteases, and antimicrobial peptides — yet how these cytotoxic effectors act in concert remains poorly understood. Here, we identify an unrecognized synergy between oxidative and non-oxidative neutrophil defenses. We show that myeloperoxidase-derived hypohalous acids selectively halogenate α...

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Literature Corpus work: ecbb0022-8791-5660-9b34-14a049566c88
DOI: 10.1101/2023.11.01.565105

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