Article

Pneumococcal H <sub>2</sub> O <sub>2</sub> Reshapes Mitochondrial Function and Reprograms Host Cell Metabolism

2025-05-22

Abstract excerpt

Streptococcus pneumoniae (Spn), a primary cause of pneumonia, induces acute lung parenchymal damage through a unique metabolic pathway generating hydrogen peroxide (H 2 O 2 ) as a byproduct. This study demonstrates that Spn-derived H 2 O 2 , primarily produced by pyruvate oxidase (SpxB), inhibits key tricarboxylic acid (TCA) cycle enzymes (aconitase, glutamate dehydrogenase, and α-ketoglutarate dehydrogenase)...

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Literature Corpus work: 5b160977-53c9-5bdd-875f-c160c7101d46
DOI: 10.1101/2025.05.22.655446

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Pneumococcal H <sub>2</sub> O <sub>2</sub> Reshapes Mitochondrial Function and Reprograms Host Cell MetabolismDOI 10.1101/2025.05.22.655446Read

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