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Article

Role of lactylation-induced macrophage failed phenotypic switching in sustaining inflammation of diabetic wounds.

Frontiers in immunology - 1 Jan 2026

Wang Jiatong, Wang Kairui, Hu Zhihan, Wang Yunwei, Kang Yuchen, Liu Xiaohui, Zhang Yuheng, Liu Yi

Abstract excerpt

The impaired healing of diabetic wounds is closely associated with a persistent inflammatory response, wherein macrophages, as crucial immune effector cells in the local wound microenvironment, play a vital role in maintaining inflammatory equilibrium. Increasing evidence indicates that lactate, a product of glycolysis, is now recognized as a novel regulator of macrophage function by influencing gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41869297
DOI: 10.3389/fimmu.2026.1777272
PMCID: PMC13002385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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