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Article

Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta.

The Journal of clinical investigation - 1 Mar 2007

Cheung Yuk Yin, Kim So Youn, Yiu Wai Han, Pan Chi-Jiunn, Jun Hyun-Sik, Ruef Robert A, Lee Eric J, Westphal Heiner, Mansfield Brian C, Chou Janice Y

Abstract excerpt

Neutropenia and neutrophil dysfunction are common in many diseases, although their etiology is often unclear. Previous views held that there was a single ER enzyme, glucose-6-phosphatase-alpha (G6Pase-alpha), whose activity--limited to the liver, kidney, and intestine--was solely responsible for...

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Identifiers

PMID: 17318259
DOI: 10.1172/JCI30443
PMCID: PMC1797608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17318259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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