Article

Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD

2019-01-01

Abstract excerpt

Neutrophils are the key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. They deploy pre-formed proteases packaged within cytoplasmic granules, generate reactive oxygen species and release neutrophil extracellular traps (NETs). However, these anti-microbial strategies can also cause substantial bystander tissue injury. Infected and inflamed tissues are profoundly...

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Literature Corpus work: 9d4dc2c4-5e54-5209-848a-bd49ea9211cd
DOI: 10.17863/cam.40594

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