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Article

Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production.

Molecular biology of the cell - 1 Nov 2014

Wang Bin, Liu Ting-Yu, Lai Chun-Hsiang, Rao Yan-hua, Choi Moon-Chang, Chi Jen-Tsan, Dai Jian-wu, Rathmell Jeffrey C, Yao Tso-Pang

Abstract excerpt

Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immunometabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysaccharide (LPS). Surprisingly, prolonged LPS treatment leads to HDAC4 degradation. LPS-induced HDAC4 degradation...

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Source

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Identifiers

PMID: 25187650
DOI: 10.1091/mbc.E13-12-0757
PMCID: PMC4214777

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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