Article

The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> The leukocyte NADPH oxidase 2 (NOX2) is an important regulator of inflammatory responses, independent of its antimicrobial activity. Inactivating mutations in NOX2 cause chronic granulomatous disease (CGD), a severe immunodeficiency associated with recurrent infections and dysregulated neutrophilic inflammation. Recurrent oral ulcers, stomatitis, gingivitis, and other inflammatory issues affecti...

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Literature Corpus work: d21b3dc9-ef2a-5a11-b669-3d61f7e3dc1b
DOI: 10.1101/2025.08.26.671820

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