Article
A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder.
American journal of human genetics - 4 Dec 2014
Duan Jubao, Shi Jianxin, Fiorentino Alessia, Leites Catherine, Chen Xiangning, Moy Winton, Chen Jingchun, Alexandrov Boian S, Usheva Anny, He Deli, Freda Jessica, O'Brien Niamh L, McQuillin Andrew, Sanders Alan R, Gershon Elliot S, DeLisi Lynn E, Bishop Alan R, Gurling Hugh M D, Pato Michele T, Levinson Douglas F, Kendler Kenneth S, Pato Carlos N, Gejman Pablo V
Abstract excerpt
Schizophrenia (SZ) genome-wide association studies (GWASs) have identified common risk variants in >100 susceptibility loci; however, the contribution of rare variants at these loci remains largely unexplored. One of the strongly associated loci spans MIR137 (miR137) and MIR2682 (miR2682), two microRNA genes important for neuronal function. We sequenced ∼6.9 kb MIR137/MIR2682 and upstream regulatory sequences in...
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