Article

Loss-of-function of <i>OTUD7A</i> in the schizophrenia-associated 15q13.3 deletion impairs synapse development and function in human neurons

2022-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Identifying causative gene(s) within disease-associated large genomic regions of copy number variants (CNVs) is challenging. Here, by targeted sequencing of genes within schizophrenia (SZ)-associated CNVs in 1,779 SZ cases and 1,418 controls, we identified three rare putative loss-of-function (LoF) mutations in OTU deubiquitinase 7A (OTUD7A) within the 15q13.3 deletion in cases, but none in cont...

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Literature Corpus work: dac92f13-db17-5f38-8b3a-5779cee5c066
DOI: 10.1101/2022.01.06.473910

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