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Article

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia.

Life science alliance - 1 May 2022

Mangnier Loïc, Joly-Beauparlant Charles, Droit Arnaud, Bilodeau Steve, Bureau Alexandre

Abstract excerpt

The 3D conformation of the chromatin creates complex networks of noncoding regulatory regions (distal elements) and promoters impacting gene regulation. Despite the importance of the role of noncoding regions in complex diseases, little is known about their interplay within regulatory hubs and implication in multigenic diseases such as schizophrenia. Here we show that cis-regulatory hubs (CRHs) in neurons...

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Source

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Identifiers

PMID: 35086934
DOI: 10.26508/lsa.202101156
PMCID: PMC8807870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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