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Article

Vitamin B6 is essential for serine <i>de novo</i> biosynthesis

11 Aug 2017

Abstract excerpt

Pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B6, plays an essential role in brain metabolism as a cofactor in numerous enzyme reactions. PLP deficiency in brain, either genetic or acquired, results in severe drug-resistant seizures that respond to vitamin B6 supplementation. The pathogenesis of vitamin B6 deficiency is largely unknown. To shed more light on the metabolic consequences of...

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PMID: 28801717
DOI: 10.1007/s10545-017-0061-3

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