Article

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

2022-05-18

Abstract excerpt

Inflammatory bowel diseases (IBD) are characterized by chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the metabolic consequences of chronic ER-stress on the pathophysiology of IBD remain unclear. By using in vitro , ex vivo , in vivo mouse models and patient datasets, we identif...

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Literature Corpus work: b688e889-0452-529f-91a3-70850a08ee3b
DOI: 10.1101/2022.05.17.492340

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