Article

Metabolic Rewiring and Altered Glial Differentiation in an iPSC-Derived Astrocytes Model Derived From a Nonketotic Hyperglycinemia Patient

2024-01-29

Abstract excerpt

The pathophysiology of Nonketotic Hyperglycinemia (NKH), a rare neuro-metabolic disorder associated with severe brain malformations and life-threatening neurological manifestations, remains incompletely understood. Therefore, a valid human neuronal model is essential. We aimed to investigate the impact of GLDC gene variants, which cause NKH, on cellular fitness during the differentiation process of human induced p...

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Literature Corpus work: ef85a8dc-2fb3-5d4d-b664-9daa95b5b5f1
DOI: 10.20944/preprints202401.1980.v1

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