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Article

Cell cycle regulation of folate‐mediated one‐carbon metabolism

11 Jun 2018

Abstract excerpt

Folate-mediated one-carbon metabolism (FOCM) comprises a network of interconnected folate-dependent metabolic pathways responsible for serine and glycine interconversion, de novo purine synthesis, de novo thymidylate synthesis and homocysteine remethylation to methionine. These pathways are compartmentalized in the cytosol, nucleus and mitochondria. Individual enzymes within the FOCM network compete for folate...

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PMID: 29889360
DOI: 10.1002/wsbm.1426

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