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Article

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

10 Mar 2021

Abstract excerpt

The activation of de novo serine/glycine biosynthesis in a subset of tumors has been described as a major contributor to tumor pathogenesis, poor outcome, and treatment resistance. Amplifications and mutations of de novo serine/glycine biosynthesis enzymes can trigger pathway activation; however, a large group of cancers displays serine/glycine pathway overexpression induced by oncogenic drivers and unknown...

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PMID: 33801846
DOI: 10.3390/cancers13061191

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