Article

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

2020-03-04

Abstract excerpt

A hallmark of metastasis is the adaptation of tumor cells to new environments. Although it is well established that the metabolic milieu of the brain is severely deprived of nutrients, particularly the amino acids serine and its catabolite glycine, how brain metastases rewire their metabolism to survive in the nutrient-limited environment of the brain is poorly understood. Here we demonstrate that cell-intrinsic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: afd816bc-cbe9-526a-a08a-fbc363d5c054
DOI: 10.1101/2020.03.03.974980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain MetastasisDOI 10.1101/2020.03.03.974980Read

An <i>in vivo</i> screen identifies NAT10 as a master regulator of brain metastasisSemantic proximity Read

Serine and glycine metabolism-related gene expression signature stratifies immune profiles of brain gliomas, and predicts prognosis and responses to immunotherapySemantic proximity Read

Linking Serine/Glycine Metabolism to Radiotherapy ResistanceSemantic proximity Read

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasisSemantic proximity Read

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathwaySemantic proximity Read

MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastomaSemantic proximity Read

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN ‐amplified neuroblastomaSemantic proximity Read

Glioma cells require one-carbon metabolism to survive glutamine starvationSemantic proximity Read

Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer MetastasisSemantic proximity Read

Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.Semantic proximity Read

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasisSemantic proximity Read

PHGDH is a targetable driver of PDAC progressionSemantic proximity Read