Drivers of de novo Serine/Glycine synthesis in acute leukemia.

Abstract excerpt

Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Leukemia, Myeloid, Acute
• Share to Mutation
• Share to Transcriptional Activation
• Share to Up-Regulation