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Article

The pattern of KRAS mutations in metastatic colorectal cancer: a retrospective audit from Sri Lanka.

BMC research notes - 10 Aug 2017

Sirisena Nirmala Dushyanthi, Deen Kemal, Mandawala Dayupathi Eranda Nipunika, Herath Pumindu, Dissanayake Vajira Harshadeva Weerabaddana

Abstract excerpt

OBJECTIVE: Activating mutations in the KRAS gene, found in approximately 53% of metastatic colorectal cancer (mCRC) cases, can render epidermal growth factor receptor (EGFR) inhibitors ineffective. Regional differences in these mutations have been reported. This is the first study which aims to describe the pattern of KRAS mutations in a Sri Lankan cohort of mCRC patients. RESULTS: The KRAS genotypes detected in...

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Identifiers

PMID: 28797274
DOI: 10.1186/s13104-017-2731-5
PMCID: PMC5553606

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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