KRAS mutation and its association with clinicopathological features of colorectal cancer patients in Africa: a systematic review and meta-analysis.

doi:10.1186/s12885-025-15356-6

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Article

KRAS mutation and its association with clinicopathological features of colorectal cancer patients in Africa: a systematic review and meta-analysis.

BMC cancer - 7 Jan 2026

Kassaw Altaseb Beyene, Abera Mihiret Bogale, Seid Mohammed Abdu, Jemal Mohammed, Ahmed Hassen, Asfaw Mulu Shiferaw, Abebe Gashaw, Alem Addis, Geto Zeleke

Abstract excerpt

BACKGROUND: Mutations in the KRAS gene serve as significant oncogenic drivers in colorectal cancer (CRC), greatly affecting therapy response and prognosis. While the prevalence and clinical significance of KRAS mutations have been extensively documented in Western populations, information from African contexts remains limited and inconsistent. Therefore, this study aimed to determine the pooled frequency of KRAS...

Topics

Humans
Colorectal Neoplasms
Mutation
Proto-Oncogene Proteins p21(ras)
Africa

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Open in PubMed Open full text

Identifiers

PMID: 41501706
DOI: 10.1186/s12885-025-15356-6
PMCID: PMC12781257

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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