Article
KRAS Mutation Status in Bulgarian Patients with Advanced and Metastatic Colorectal Cancer.
International journal of molecular sciences - 13 Aug 2023
Radanova Maria, Mihaylova Galya, Stoyanov George St, Draganova Vyara, Zlatarov Aleksandar, Kolev Nikola, Dimitrova Eleonora, Conev Nikolay, Ivanova Diana
Abstract excerpt
RAS somatic variants are predictors of resistance to anti-EGFR therapy for colorectal cancer (CRC) and affect the outcome of the disease. Our study aimed to evaluate the frequency of RAS, with a focus on KRAS variants, and their association with tumor location and some clinicopathological characteristics in Bulgarian CRC patients. We prospectively investigated 236 patients with advanced and metastatic CRC....
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