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Article

Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.

Pathology, research and practice - 1 Jan 2009

Neumann Jens, Zeindl-Eberhart Evelyn, Kirchner Thomas, Jung Andreas

Abstract excerpt

Mutation analysis of the KRAS oncogene is now established as a predictive biomarker in colorectal cancer (CRC). Large prospective clinical trials have shown that only CRCs with wild-type KRAS respond to anti-epidermal growth factor receptor (EGFR) treatment. Therefore, mutation analysis is mandatory before treatment, and reliable benchmarks for the frequency and types of KRAS mutations have to be established for...

Read the complete abstract on PubMed

Topics

Aged
Antineoplastic Agents
Biomarkers, Tumor
Codon
Cohort Studies
Colorectal Neoplasms
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

ErbB Receptors

Female

Gene Expression Regulation, Neoplastic

Genetic Testing

Humans

Male

Middle Aged

Mutation

Patient Selection

Predictive Value of Tests

Protein Kinase Inhibitors

Source

Identifiers

PMID: 19679400
DOI: 10.1016/j.prp.2009.07.010

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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