Article

Frequency and Type of KRAS Mutations in Routine Diagnostic Analysis of Metastatic Colorectal Cancer

2009-10-01

Abstract excerpt

Aims: Mutation analysis of the KRAS oncogene is now established as a predictive biomarker in colorectal cancer (CRC). Large prospective clinical trials showed that only CRCs with wild type KRAS respond to anti-epidermal growth factor receptor (EGFR) treatment. Therefore the mutation analysis is mandatory before treatment and reliable benchmarks of the frequency and types of KRAS -mutations have to be established f...

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Literature Corpus work: 294fb46e-14ea-5a68-8c42-d4046c05d028
DOI: 10.1055/s-0029-1242277

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