Article
Molecular spectrum of KRAS, BRAF, and PIK3CA gene mutation: determination of frequency, distribution pattern in Indian colorectal carcinoma.
Medical oncology (Northwood, London, England) - 1 Sept 2014
Bisht Swati, Ahmad Firoz, Sawaimoon Satyakam, Bhatia Simi, Das Bibhu Ranjan
Abstract excerpt
Molecular evaluation of KRAS, BRAF, and PIK3CA mutation has become an important part in colorectal carcinoma evaluation, and their alterations may determine the therapeutic response to anti-EGFR therapy. The current study demonstrates the evaluation of KRAS, BRAF, and PIK3CA mutation using direct sequencing in 204 samples. The frequency of KRAS, BRAF, and PIK3CA mutations was 23.5, 9.8, and 5.9 %, respectively....
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Class I Phosphatidylinositol 3-Kinases
- Cohort Studies
- Colorectal Neoplasms
- Female
- Humans
- India
- Male
- Middle Aged
- Mutation
- Phosphatidylinositol 3-Kinases