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Article

[The frequency and spectrum of KRAS mutations in metastatic colorectal cancer].

Voprosy onkologii - 1 Jan 2013

Mazurenko N N, Gagarin I M, Tsyganova I V, Mochal'nikova V V, Breder V V

Abstract excerpt

KRAS mutations in patients with metastatic colorectal cancer (CRC) are a negative marker of the effectiveness of anti-EGFR therapy and have prognostic significance. KRAS genotyping was performed in the material from patients with metastatic CRC. KRAS mutations were determined in tumor DNA from archival biopsies of 573 patients using PCR and sequencing. Mutations in the exon 2 of the KRAS gene were detected in...

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Identifiers

PMID: 24624786

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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