Article
Prognostic Differences of RAS Mutations: Results from the South Australian Metastatic Colorectal Registry.
Targeted oncology - 1 Jan 2022
Alawawdeh Anas, Piantadosi Cynthia, Townsend Amanda Rose, Karapetis Christos Stelios, Padbury Rob, Roy Amitesh Chandra, Moore James, Maddern Guy, Roder David, Smith Annabelle, Price Timothy Jay
Abstract excerpt
BACKGROUND: Effective targeting of RAS mutations has proven elusive until recently. Novel agents directly targeting KRAS G12C have shown promise in early-phase clinical trials that included patients with metastatic colorectal cancer. Prior reports have suggested that G12C mutation may be predictive of poor outcome. OBJECTIVE: Assessment of the specific characteristics and prognostic implications of individual RAS...
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