Article
KRAS mutations: variable incidences in a Brazilian cohort of 8,234 metastatic colorectal cancer patients.
BMC gastroenterology - 10 Apr 2014
Gil Ferreira Carlos, Aran Veronica, Zalcberg-Renault Ilana, Victorino Ana Paula, Salem Jonas H, Bonamino Martin H, Vieira Fernando M, Zalis Mariano
Abstract excerpt
BACKGROUND: KRAS mutations are frequently found in colorectal cancer (CRC) indicating the importance of its genotyping in the study of the molecular mechanisms behind this disease. Although major advances have occurred over the past decade, there are still important gaps in our understanding of CRC carcinogenesis, particularly whether sex-linked factors play any role. METHODS: The profile of KRAS mutations in the...
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