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Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.

Molecular and cellular biology - 15 Nov 2017

Reubens Michael C, Rozenzhak Sophie, Russell Paul

Abstract excerpt

DNA replication involves the inherent risk of genome instability, since replisomes invariably encounter DNA lesions or other structures that stall or collapse replication forks during the S phase. In the fission yeast Schizosaccharomyces pombe, the multi-BRCT domain protein Brc1, which is related to budding yeast Rtt107 and mammalian PTIP, plays an important role in maintaining genome integrity and cell viability...

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PMID: 28784724
DOI: 10.1128/MCB.00260-17
PMCID: PMC5660468

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