Article
The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.
Genetics - 1 Feb 2012
Garabedian Mikael V, Noguchi Chiaki, Ziegler Melissa A, Das Mukund M, Singh Tanu, Harper Logan J, Leman Adam R, Khair Lyne, Moser Bettina A, Nakamura Toru M, Noguchi Eishi
Abstract excerpt
Bromodomain proteins bind acetylated histones to regulate transcription. Emerging evidence suggests that histone acetylation plays an important role in DNA replication and repair, although its precise mechanisms are not well understood. Here we report studies of two double bromodomain-containing proteins, Bdf1 and Bdf2, in fission yeast. Loss of Bdf1 or Bdf2 led to a reduction in the level of histone H4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.