Brc1-dependent recovery from replication stress.

doi:10.1242/jcs.103119

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Article

Brc1-dependent recovery from replication stress.

Journal of cell science - 1 Jun 2012

Bass Kirstin L, Murray Johanne M, O'Connell Matthew J

Abstract excerpt

BRCT-containing protein 1 (Brc1) is a multi-BRCT (BRCA1 carboxyl terminus) domain protein in Schizosaccharomyces pombe that is required for resistance to chronic replicative stress, but whether this reflects a repair or replication defect is unknown and the subject of this study. We show that brc1Δ cells are significantly delayed in recovery from replication pausing, though this does not activate a DNA damage...

Topics

DNA Replication
DNA, Ribosomal
Hydroxyurea
Mutagenesis
Mutation
Origin Recognition Complex
Rad52 DNA Repair and Recombination Protein
Recombination, Genetic
Replication Protein A
S Phase
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Signal Transduction
Stress, Physiological

Source

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Identifiers

PMID: 22366461
DOI: 10.1242/jcs.103119
PMCID: PMC3403237

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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