Article
Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.
G3 (Bethesda, Md.) - 19 Mar 2015
Sánchez Arancha, Roguev Assen, Krogan Nevan J, Russell Paul
Abstract excerpt
Brc1, which was first identified as a high-copy, allele-specific suppressor of a mutation impairing the Smc5-Smc6 holocomplex in Schizosaccharomyces pombe, protects genome integrity during normal DNA replication and when cells are exposed to toxic compounds that stall or collapse replication forks. The C-terminal tandem BRCT (BRCA1 C-terminus) domain of fission yeast Brc1 docks with phosphorylated histone H2A...
Topics
- DNA Damage
- Epistasis, Genetic
- Gene Expression
- Gene Knockout Techniques
- Gene Ontology
- Histones
- Mutagens
- Mutation
- Rad52 DNA Repair and Recombination Protein
- Replication Protein A
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins