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Article

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1 Jan 1997

Abstract excerpt

Computer analysis of a conserved domain, BRCT, first described at the carboxyl terminus of the breast cancer protein BRCA1, a p53 binding protein (53BP1), and the yeast cell cycle checkpoint protein RAD9 revealed a large superfamily of domains that occur predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain consists of approximately 95 amino acid residues...

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Identifiers

PMID: 9034168
DOI: 10.1096/fasebj.11.1.9034168

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A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteinsPMID 9034168Read ↗

BRCT Domain Interactions in the Heterodimeric DNA Repair Protein XRCC1−DNA Ligase IIISemantic proximity Read ↗

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Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteinsSemantic proximity Read ↗

NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage ResponseSemantic proximity Read ↗

A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.Semantic proximity Read ↗

BRCT domains: phosphopeptide binding and signaling modules.Semantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against InfectionsSemantic proximity Read ↗

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

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