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Article

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.

Molecular and cellular biology - 1 Sept 2005

Collura Ada, Blaisonneau Joel, Baldacci Giuseppe, Francesconi Stefania

Abstract excerpt

Living organisms experience constant threats that challenge their genome stability. The DNA damage checkpoint pathway coordinates cell cycle progression with DNA repair when DNA is damaged, thus ensuring faithful transmission of the genome. The spindle assembly checkpoint inhibits chromosome segregation until all chromosomes are properly attached to the spindle, ensuring accurate partition of the genetic...

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Identifiers

PMID: 16107732
DOI: 10.1128/MCB.25.17.7889-7899.2005
PMCID: PMC1190313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.PMID 16107732Read ↗

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