Article
The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.
Molecular and cellular biology - 1 Sept 2005
Collura Ada, Blaisonneau Joel, Baldacci Giuseppe, Francesconi Stefania
Abstract excerpt
Living organisms experience constant threats that challenge their genome stability. The DNA damage checkpoint pathway coordinates cell cycle progression with DNA repair when DNA is damaged, thus ensuring faithful transmission of the genome. The spindle assembly checkpoint inhibits chromosome segregation until all chromosomes are properly attached to the spindle, ensuring accurate partition of the genetic...
Topics
- Alleles
- Camptothecin
- Cell Cycle
- Cell Cycle Proteins
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- Chromosomes, Fungal
- DNA Damage
- DNA Replication
- DNA Topoisomerases, Type I
- DNA, Fungal
- Drug Resistance, Fungal
- Enzyme Inhibitors