Article
Rad18 is required for DNA repair and checkpoint responses in fission yeast.
Molecular biology of the cell - 1 Sept 1999
Verkade H M, Bugg S J, Lindsay H D, Carr A M, O'Connell M J
Abstract excerpt
To survive damage to the genome, cells must respond by activating both DNA repair and checkpoint responses. Using genetic screens in the fission yeast Schizosaccharomyces pombe, we recently isolated new genes required for DNA damage checkpoint control. We show here that one of these strains defines a new allele of the previously described rad18 gene, rad18-74. rad18 is an essential gene, even in the absence of...
Topics
- Adenosine Triphosphate
- Alleles
- Binding Sites
- Cell Cycle
- Checkpoint Kinase 1
- Chromatin
- Chromosomes, Fungal
- DNA Damage
- DNA Repair
- DNA Topoisomerases, Type II
- DNA-Binding Proteins