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Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.

Molecular biology of the cell - 1 Aug 2006

Taricani Lorena, Wang Teresa S F

Abstract excerpt

Rad4TopBP1, a BRCT domain protein, is required for both DNA replication and checkpoint responses. Little is known about how the multiple roles of Rad4TopBP1 are coordinated in maintaining genome integrity. We show here that Rad4TopBP1 of fission yeast physically interacts with the checkpoint sensor proteins, the replicative DNA polymerases, and a WD-repeat protein, Crb3. We identified four novel mutants to...

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Identifiers

PMID: 16723501
DOI: 10.1091/mbc.e06-01-0056
PMCID: PMC1525248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.PMID 16723501Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress.Semantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.Semantic proximity Read ↗

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Semantic proximity Read ↗

Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.Semantic proximity Read ↗

Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.Semantic proximity Read ↗

Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.Semantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9Semantic proximity Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

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