Article
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
The Journal of biological chemistry - 6 Jul 2012
Islam M Nurul, Paquet Nicolas, Fox David, Dray Eloise, Zheng Xiao-Feng, Klein Hannah, Sung Patrick, Wang Weidong
Abstract excerpt
The BRC repeat is a structural motif in the tumor suppressor BRCA2 (breast cancer type 2 susceptibility protein), which promotes homologous recombination (HR) by regulating RAD51 recombinase activity. To date, the BRC repeat has not been observed in other proteins, so that its role in HR is inferred only in the context of BRCA2. Here, we identified a BRC repeat variant, named BRCv, in the RECQL5 helicase, which...
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