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Article

Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress.

The Journal of biological chemistry - 23 Mar 2007

Taricani Lorena, Wang Teresa S F

Abstract excerpt

Rad4(TopBP1) is a scaffold in a protein complex containing both replication proteins and checkpoint proteins and plays essential roles in both replication and checkpoint responses. We have previously identified four novel fission yeast mutants of rad4+(TopBP1) to explore how Rad4(TopBP1), a single protein, can play multiple roles in genomic integrity maintenance. Among the four novel mutants, rad4-c17(TopBP1) is...

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PMID: 17272281
DOI: 10.1074/jbc.M609282200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress.PMID 17272281Read ↗

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.Semantic proximity Read ↗

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.Semantic proximity Read ↗

The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.Semantic proximity Read ↗

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.Semantic proximity Read ↗

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read ↗

Characterisation of non-essential genes required for survival under conditions of DNA stressSemantic proximity Read ↗

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.Semantic proximity Read ↗

TORC2 is required to maintain genome stability during S phase in fission yeast.Semantic proximity Read ↗

Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.Semantic proximity Read ↗

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.Semantic proximity Read ↗

The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.Semantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

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