Article
Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Apr 2018
Marrón-Liñares Grecia M, Núñez Lucía, Crespo-Leiro María G, Barge-Caballero Eduardo, Pombo Jorge, Paniagua-Martin María Jesús, Suarez-Fuentetaja Natalia, Cid Javier, Grille-Cancela Zulaika, Muñiz-Garcia Javier, Tan Carmela D, Rodríguez E Rene, Vázquez-Rodríguez José Manuel, Hermida-Prieto Manuel
Abstract excerpt
BACKGROUND: Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). Complement activation plays a key role in AMR contributing to graft damage. The aim of this study was to analyze genetic variants in genes related to the complement pathways that could be associated with the...
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