Article
Donor Polymorphisms in Genes Related to B-Cell Biology Associated With Antibody-Mediated Rejection After Heart Transplantation.
Circulation journal : official journal of the Japanese Circulation Society - 25 Apr 2018
Marrón-Liñares Grecia M, Núñez Lucía, Crespo-Leiro María G, Álvarez-López Eloy, Barge-Caballero Eduardo, Barge-Caballero Gonzalo, Couto-Mallón David, Pradas-Irun Concepción, Muñiz Javier, Tan Carmela, Rodríguez E Rene, Vázquez-Rodríguez José Manuel, Hermida-Prieto Manuel
Abstract excerpt
BACKGROUND: Heart transplantation (HT) is a well-established lifesaving treatment for endstage cardiac failure. Antibody-mediated rejection (AMR) represents one of the main problems after HT because of its diagnostic complexity and the poor evidence for supporting treatments. Complement cascade and B-cells play a key role in AMR and contribute to graft damage. This study explored the importance of variants in...
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