MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation.

doi:10.3389/fimmu.2024.1440887

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Article

MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation.

Frontiers in immunology - 1 Jan 2024

Littera Roberto, Mocci Stefano, Argiolas Davide, Littarru Letizia, Lai Sara, Melis Maurizio, Sanna Celeste, Mereu Caterina, Lorrai Michela, Mascia Alessia, Angioi Andrea, Mascia Giacomo, Matta Valeria, Lepori Nicola, Floris Matteo, Manieli Cristina, Bianco Paola, Onnis Daniela, Rassu Stefania, Deidda Silvia, Carta Mauro Giovanni, Giuressi Erika, Perra Andrea, Chessa Luchino, Giglio Sabrina, Pani Antonello

Abstract excerpt

Background: Antibody-mediated rejection is a significant cause of kidney transplant failure. Recent studies have shown that the MHC class I MICA gene influences the transplantation outcome. However, the role of the primary MICA receptor, NKG2D, has yet to be explored. Aim: We aimed to investigate the correlation between recipient/donor MICA allele matching and NKG2D genotype with the risk of antibody-mediated...

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Identifiers

PMID: 39575256
DOI: 10.3389/fimmu.2024.1440887
PMCID: PMC11578996

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