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Article

MBL2 deficiency and IgA Nephropathy in transplant patients: Is complement inhibition always beneficial?

European journal of internal medicine - 1 Jun 2026

Stea Emma Diletta, Pesce Francesco, Bari Ighli di, Franzin Rossana, Rossini Michele, Simone Simona, Piancone Fausta, Sallustio Fabio, De Palma Arianna, Grignano Maria Antonietta, Pontrelli Paola, Gregorini Marilena, Islami Tefik, Rampino Teresa, Castellano Giuseppe, Gesualdo Loreto

Abstract excerpt

IgA nephropathy (IgAN) is a leading cause of End-Stage Renal Disease, with kidney transplantation as the preferred treatment, although with unpredictable and diverse outcomes. Mannose-binding lectin (MBL), a key component of the lectin pathway (LP), is associated with IgAN, and both excessive and deficient levels may exacerbate the disease. Genetic variants in MBL2 affect MBL serum levels and function,...

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Source

Identifiers

PMID: 41708441
DOI: 10.1016/j.ejim.2026.106765

Genes

MBL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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