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Article

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight - 8 Sept 2021

de Mattos Barbosa Mayara Garcia, Lefferts Adam R, Huynh Daniel, Liu Hui, Zhang Yu, Fu Beverly, Barnes Jenna, Samaniego Milagros, Bram Richard J, Geha Raif S, Shikanov Ariella, Prak Eline T Luning, Farkash Evan A, Platt Jeffrey L, Cascalho Marilia

Abstract excerpt

Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-mediated injury of transplants, by regulating innate B cells' functions. Analysis of TNFRSF13B in human kidney transplant recipients revealed that 33% of those with...

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Identifiers

PMID: 34283811
DOI: 10.1172/jci.insight.150483
PMCID: PMC8492324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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