Article
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes.
Rheumatology international - 1 Oct 2017
García-Ibarbia Carmen, Neila Sara, Garcés Carlos, Alonso Maria A, Zarrabeitia María T, Valero Carmen, Ortiz Fernando, Riancho José A
Abstract excerpt
Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA phenotype. We studied 509 Caucasian patients undergoing joint replacement due to severe primary OA. Radiographs were used to classify the OA as atrophic or hypertrophic. Two nonsynonymous polymorphisms of...
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