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Article

Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.

Osteoarthritis and cartilage - 1 Oct 2008

Kerkhof J M, Uitterlinden A G, Valdes A M, Hart D J, Rivadeneira F, Jhamai M, Hofman A, Pols H A P, Bierma-Zeinstra S M A, Spector T D, van Meurs J B

Abstract excerpt

OBJECTIVE: To examine the association of genetic variation in key players in the Wnt signaling pathway with aspects of osteoarthritis (OA) in two population-based cohort studies: the Rotterdam Study and the Chingford Study. METHODS: Radiographic OA (ROA) was defined as a Kellgren/Lawrence score (K/L) score > or = 2 for the knee and hip. Total hip replacement (THR) was scored. Hand OA was defined as presence of...

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Source

Identifiers

PMID: 18406176
DOI: 10.1016/j.joca.2008.02.007

Genes

FRZB
LRP5
LRP6
CMC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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