Article
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
PLoS genetics - 1 Jul 2012
Medina-Gomez Carolina, Kemp John P, Estrada Karol, Eriksson Joel, Liu Jeff, Reppe Sjur, Evans David M, Heppe Denise H M, Vandenput Liesbeth, Herrera Lizbeth, Ring Susan M, Kruithof Claudia J, Timpson Nicholas J, Zillikens M Carola, Olstad Ole K, Zheng Hou-Feng, Richards J Brent, St Pourcain Beate, Hofman Albert, Jaddoe Vincent W V, Smith George Davey, Lorentzon Mattias, Gautvik Kaare M, Uitterlinden André G, Brommage Robert, Ohlsson Claes, Tobias Jonathan H, Rivadeneira Fernando
Abstract excerpt
To identify genetic loci influencing bone accrual, we performed a genome-wide association scan for total-body bone mineral density (TB-BMD) variation in 2,660 children of different ethnicities. We discovered variants in 7q31.31 associated with BMD measurements, with the lowest P = 4.1 × 10(-11) observed for rs917727 with minor allele frequency of 0.37. We sought replication for all SNPs located ± 500 kb from...
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