Article
A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2023
Faber Benjamin G, Frysz Monika, Hartley April E, Ebsim Raja, Boer Cindy G, Saunders Fiona R, Gregory Jennifer S, Aspden Richard M, Harvey Nicholas C, Southam Lorraine, Giles William, Le Maitre Christine L, Wilkinson J Mark, van Meurs Joyce B J, Zeggini Eleftheria, Cootes Timothy, Lindner Claudia, Kemp John P, Davey Smith George, Tobias Jonathan H
Abstract excerpt
OBJECTIVE: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip osteoarthritis (OA). METHODS: Observational analyses examined associations between AA measurements derived from hip dual x-ray absorptiometry (DXA) scans from the UK...
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